Name:

Dr Patricia Rousselle

Work address:

Cell / microenvironment cross-talk and tissue repair lab
Biologie Tissulaire et Ingénierie Thérapeutique Department
UMR 5305 - CNRS/UCBLyon 1- SFR BioSciences Gerland-Lyon Sud
7 passage du Vercors
69367 Lyon Cedex 07, France

Present position:

Research director – group leader

President of the French Society for Matrix Biology

Board member of the European Society for Tissue Repair

Telephone number:

+33 (0)4 72 72 26 39

Email:

This email address is being protected from spambots. You need JavaScript enabled to view it.

Website:

https://lbti.ibcp.fr

Facebook/Twitter/LinkedIn etc details

https://www.linkedin.com/in/patricia-rousselle-b1333019/
https://www.researchgate.net/profile/Patricia_Rousselle
https://orcid.org/0000-0003-0275-4562

Relevant key descriptors of your academic/industrial/
clinical expertise or future interests:

Research interests – cell adhesion, cell migration, cellular imaging, wound healing, epidermal regeneration, keratinocyte, extracellular matrix,  basement membrane, integrin, syndecan

 

Academic/industrial/clinical collaborations/links:

Academic links – Lyon University 

Work closely with clinical colleagues at Burn centre of Lyon Hospital (ANR Grant) http://www.internationalinnovation.com/build/wp-content/uploads/2015/01/p71-73_Patricia_Rousselle_Intl_Innovation_170_Research_Media.pdf 

Collaboration with several cosmetic and dermo-cosmetic industry (BASF, Ales groupe, Laboratoire d’Anjou)

Editorial boards/grant panels:

Grant panel member for the National French Agency (ANR), therapeutic innovation department

Relevant papers/book chapters/patents/clinical guidelines etc:

Selected papers from last 10 years:

1. Mainzer C, Remoué N, Molinari J, Rousselle P, Barricchello C, Lago J, Sommer P, Sigaudo-Roussel D, Debret D. In vitro epidermis model mimicking IGF-1 specific age-related decline. (in press)

2. Rousselle P, Montmasson M, Garnier C. Extracellular matrix contribution to skin wound re-epithelialization. Matrix Biol. 2018 Jan 10. pii: S0945-053X(17)30314-1.

3. Jobeili L, Rousselle P, Béal D, Blouin D, Roussel AM, Damour O and Rachidi W. Selenium preserves keratinocyte stemness and prevents senescence by maintaining epidermal adhesion. Aging, 2017 Nov 25;9(11):2302-2315.

4. Koelblen T, Bergé C, Cherrier MV, Brillet K, Jimenez-Soto L, Ballut L, Takagi J, Montserret R, Rousselle P, Fischer W, Haas R, Fronzes R and Terradot L. Molecular dissection of protein-protein interactions between integrin α5β1 and the Helicobacter pylori Cag Type IV secretion system. FEBS J. 2017 Oct 21. doi: 10.1111/febs.14299.

5. Rovere MR, Rousselle P, Haftek M, Charleuxe B, Kocabaa V, Auxenfans C, Nataf S, Damour O. Preserving basement membranes during detachment of cultivated oral mucosal epithelial cell sheets for the treatment of total bilateral limbal stem cell deficiency. Cell Transplantation. 2017 (in press)

6. Bonnet I, Jobeili L, Cadau S, Berthélémy N, Pierrot A, Tedeschi C, Bardey V, Fargier G, Rival D, Jeanmaire C., Bonnaud-Rosaye C, Chan W, Chavan M, André-Frei V, Zahouani H and Rousselle P. Collagen XVIII : A key interfacial component of the skin architecture. J. Cosmet. Sci. 2017; 68: 35–41.

7. Cheng B, Montmasson M, Terradot L, Rousselle P. Syndecans as Cell Surface Receptors in Cancer Biology. A Focus on their Interaction with PDZ Domain Proteins. Front Pharmacol. 2016 Feb 2;7:10.

8. Dos Santos M, Michopoulou A, André-Frei V, Guicher C, Boulesteix S, Dayan G, Whitelock J, Damour O and Rousselle P. Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin. Aging. 2016 ;8:751-68.

9. Rousselle P, Gentilhomme E, Neveux Y. Epidermal physiology. Measuring the Skin Editors P. Agache and P. Humbert. “Humbert P, Maibach H, Fanian F et al (2016) Agache’s Measuring the Skin. Second edition. Springer International Publishing pp. 397-405. doi: 10.1007/978-3-319-26594-0_36-1

10. Rousselle P, Gentilhomme E, Neveux Y. Markers of epidermal prolifération and differentiation. “Humbert P, Maibach H, Fanian F et al (2016) Agache’s Measuring the Skin. Second edition. Springer International Publishing pp. 407-415. doi: 10.1007/978-3-319-26594-0_37-1.

11. Michopoulou A. and Rousselle P. How do epidermal matrix metalloproteinases support re-epithelialization during skin healing ? Eur J Dermatol. 2015 Apr ;25 Suppl 1:33-42.

12. Dos Santos M, Metral E, Boher A, Rousselle P, Thepot A, Damour O. In vitro 3-D model based on extending time of culture for studying chronological epidermis aging. Matrix Biol. 2015, 47:85-97.

13. Rousselle P and Michopoulou A. Laminin 332 in epidermolysis bullosa and autoimmune blistering diseases. In Blistering Diseases : Clinical Features, Pathogenesis, Treatment, Publisher : Springer Berlin Heidelberg, Editors: Dédée F. Murrell, 2015, pp.91-102.

14. Senyürek I, Kempf WE, Klein G, Maurer A, Kalbacher H, Schäfer L, Wanke I, Christ C, Stevanovic S, Schaller M, Rousselle P, Garbe C, Biedermann T, Schittek B (2014) Processing of Laminin α Chains Generates Peptides Involved in Wound Healing and Host Defense. J Innate Immun, 2014, 6:467-84.

15. Rousselle P, Carulli S, Chajra H, Dayan G, Pin D and Herbage B (2013) The syndecan binding sequence KKLRIKSKEK in laminin α3 LG4 domain promotes epidermal repair. Eur J Dermatol 23:57-65.

16. Rousselle P and Beck K (2013) Laminin 332 processing impacts cellular behavior. Cell Adh Migr 7: 122-134.

17. Bernard P, Antonicelli F, Bedane C, Joly P, Le Roux-Villet C, Duvert-Lehembre S, Rousselle P and Prost-Squarcioni C (2013) Prevalence and clinical significance of anti-Laminin 332 autoantibodies detected by a novel ELISA in mucous membrane pemphigoid. JAMA Dermatol 20: 1-8.

18.  Hansson A, Di Francesco T, Falson F, Rousselle P, Jordan O and Borchard G (2012) Preparation and evaluation of nanoparticles for directed tissue engineering. Int J Pharm 439:73-80.

19. Bonod-Bidaud C, Roulet M, Hansen U, Elsheikh A, Malbouyres M, Ricard-Blum S, Faye C, Vaganay E, Rousselle P and Ruggiero F (2012) In vivo evidence for a bridging role of a collagen V subtype at the epidermis-dermis interface. J Invest Dermatol 132: 1841-1849.

20. Carulli S, Beck K, Dayan G, Boulesteix S, Lortat-Jacob H and Rousselle P (2012) The cell surface proteoglycan syndecan-1 and -4 bind overlapping but distinct sites in the laminin α3 LG4 domain through different mechanisms. J Biol Chem 287: 12204-12216.

21. Sime W, Lunderius-andersson C, Enoksson M, Rousselle P, Tryggvason K, Nilsson G, Harvima I and Patarroyo M (2009) Human Mast Cells Adhere To And Migrate On Epithelial And Vascular Basement Membrane Laminins Lm-332 And Lm-511 Via {alpha}3{beta}1 Integrin. J Immunol 183: 4657-65.

22. Armanet M, Wojtusciszyn A, Morel P, Parnaud G, Rousselle P, Sinigaglia C, Berney T, Bosco D (2009) Regulated Laminin-332 Expression In Human Islets Of Langerhans. Faseb J 23: 4046-5563.

23. Vuoristo S, Virtanen I, Takkunen M, Palgi J, Kikkawa Y, Rousselle P, Sekiguchi K, Tuuri T, Otonkoski T (2009) Laminin isoforms in human embryonic stem cells: Synthesis, receptor usage and growth Support. J Cell Mol Med 13: 2622-2633.

24. Sulka B, Lortat-Jacob H, Terreux R, Letourneur F and Rousselle P (2009) Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitement. J Biol Chem 284: 10659-10671.

25. Tran M*, Rousselle P*, Nokelainen P, Tallapragada S, Nguyen N, Fincher E and Marinkovich MP (2008) Targeting a tumor specific laminin domain critical for human carcinogenesis. Cancer Res 68: 2885-2894. *equal contribution

26. Bachy S, Letourneur F and Rousselle P (2008) Syndecan-1 interaction with the LG4/5 domain in laminin-332 is essential for keratinocyte migration. J Cell Physiol 214: 238-249.

Patents:

1. Monoclonal Antibodies directed against LG4-5 domain of Alpha3 chain of human laminin-5. WO2009EP67597

2. Peptide sequence found in Laminin 5 for treating skin impairments EP1784423B1

3. Peptide promoting cell adhesion and migration. EP2406275A1/fr

4. Utilisation Cosmétique ou dermatologique d’un extrait de polygonum bisorta WO2014155012A9/fr

5. Utilisation Cosmétique d’un extrait de tapirira guyanensis EP3043873A1/fr

6. Utilisation cosmétique d’un extrait de Khaya senegalensis WO2017178751A1/fr

Available for media comment:

Yes